Skin biopsy appears to be helpful in confirming the diagnosis in these patients.Ī 59-year-old woman had a 2-year history of generalized patchy dysesthesias. Skin biopsies revealed distinctive morphologic changes with clustered terminal nerve swellings without evidence of nerve fiber degeneration.Ĭonclusions These distinct morphologic changes associated with nitrofurantoin have not been previously reported to our knowledge. Results from nerve conduction studies were normal. ![]() Results The neuropathy was neither dose dependent nor associated with impaired renal function. Main Outcome Measures Slow or incomplete recovery and possibly irreversible damage. ![]() Patients A 59-year-old woman with disabling generalized dysesthesia and a 53-year-old woman with progressive burning pain in the perineum and extremities. Setting Clinical evaluation and skin biopsies were performed at a tertiary teaching hospital in Baltimore, Maryland. Objective To investigate the role of skin biopsy in nitrofurantoin peripheral neuropathy.ĭesign We describe the clinical features and skin biopsies of 2 cases of non–length-dependent small-fiber neuropathy/ganglionopathy attributable to nitrofurantoin. Shared Decision Making and Communication. ![]() ![]() Scientific Discovery and the Future of Medicine.Health Care Economics, Insurance, Payment.Clinical Implications of Basic Neuroscience.Challenges in Clinical Electrocardiography.
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